Program overview last HTPD 2023

Program overview HTPD 2023 (tentative)

Monday October 30 – Pre-conference day / Start of conference

9.00 – 16.00 Registration desk open at Mediterranean Conference Center (MCC)

10.00 – 15.00 Chromatography Modeling Day (lunch included)

16.00 Conference start. Opening remarks

16.15 Opening seminar: Dr Martina Micheletti, UCL “Scale-down tools for rapid upstream process development: fundamentals and scaling approaches”

17.40 Welcome drink and opening reception at MCC

Tuesday October 31 (Mediterranean Conference Center (MCC)

8.00 – 12. 00 Smart Process Development – Modeling

Session chairs: Jürgen Hubbuch, KIT/ Tobias Hahn, Cytiva

8.00 – 8.15 Session intro

8.15 – 8.45 Adapting High-throughput Technologies for Mechanistic Modeling: Construct Model with the Combination of Kp and Robocolumn as a Novel Calibration Tool
Yanru Zhang, Chugai

8.45-9.15 Accelerating downstream process development using in-silico process optimization with mechanistic models  
Gabriela Sanchez, Merck&Co;

9.15 – 9.45 Mechanistic modeling of virus surrogate removal by anion exchange chromatography
Lukas Döring, Rentschler

9.45-10.15 Coffee

10.15 – 10.45 A chromatography system modeling strategy for precise in silico process scaling             
Tatjana Trunzer, Cytiva

10.45 – 11.15 Creation of a Phase I/II digital twin for a mAb MMC_AEX unit operation in flow-through mode
Erik Hinze, CSL Behring Innovation GmbH

11.15 – 11.45 Simplifying the mechanistic modeling workflow with precharacterized columns – the story from their development to application
Max Edin, Cytiva

12.00-13.00 Lunch

13.00- 17.00 Evolution of Mature HTPD Platforms

Session chairs:   John Welsh, Rivanna Bioprocess Solutions / Brian Murray, Sanofi

13.00-13.15 Session intro

13.15 – 13.45 Integrated Protein A Chromatography and Low pH Viral Inactivation Unit Operations Miniaturised on an Automated Platform               
Paras Sharma, UCL CSL Behring

13.45 – 14.15 High Throughput Screening for resin regeneration conditions
Cornelia Walther, Boehringer-Ingelheim

14.15 – 14.45 Improved DOE Workflow for Parallel Screening Experiments on the Ambr® Crossflow TFF system
Viktor Sandner, Sartorius

14.45 – 15.15 Coffee

15.15 – 15.45 High Throughput Models for Process Characterization: Successes and Challenge
Brian Murray, Sanofi

15.45 – 16.15 Micro-scale Purification Platform – High throughput tool for BioPharma Manufacturing Investigations
Manoj Ganesh  , Regeneron

17.00-19.00 Poster session

Wednesday November 1 (Mediterranean Conference Center (MCC)

9.00-12.00 Integrated PD and Analytics Case Studies

Session chairs: Jon Coffman, Astra Zeneca, / Andrea Rayat UCL

9.00 – 9.15 Session intro

9.15 – 9.45 Automated Raman spectroscopy measurements for integrated chemometric model development
Jakob Müller, KIT

9.45 – 10.15 SpecPlate, the better standard for more efficient plate based UV/Vis absorbance measurements

Carsten Radtke, PHABIOC

10.15 – 10.45 Coffee

10.45 – 11.15 Integration of Automated High Throughput Process Analytics to support High Throughput Process Development
Nicola Roberts, UCB

11.15 – 11.45 Enhancing Bioprocessing with pH Sensitive Nanosensors: High Throughput Screening and Antibody Production
Alison Tang, AstraZeneca

12.00-13.30 Lunch

13.30-15.00 Panel Discussion: Best Practices in HTPD for Regulatory Filings, Formulations, and More

Facilitator: Michael Doherty, Ring Therapeutics

15.30 Guided walking tour in Valletta (included in conference fee)

Thursday November 2 (Mediterranean Conference Center (MCC)

8.00 – 12.15 Calling All Nanoparticles: HTPD with Cells, Viral Vectors, LNPs, Gene Editors, and Vaccines

Session chair: Jack Kramarczyk, Moderna Therapeutics

8.00 – 8.15 Session intro

8.15 – 8.45 Downstream overview of an end-to-end high throughput AAV drug substance process development platform
Dr Mahsa Hadidi, Sanofi

8.45 – 9.15 Development of High-Throughput Purification Methods for Adeno-Associated Viral Vectors
Katerina Farukshina, Catapult

9.15 – 9.45 Towards High-throughput process characterization of gene therapy viral vectors
Matt Petroff, Spark Therapeutics

9.45 – 10.15 Coffee

10.15 – 10.45 Breaking boundaries in AAV platform optimisation HT monolith chromatography plate development
Nicholas Pearman, Pharmaron

10.45 – 11.15 Platform for High-Throughput Algorithmic Optimization of in vitro Transcription
Spencer McMinn, Merck

11.15 – 11.45 High-throughput Process Development for Antibody-Drug Conjugate (ADC)
Benjamin Fabre, Sanofi

12.00 – 13.15 Lunch

13.15-16.30 Frontiers in HTPD/Smart PD 

Session chairs: Felix Wittkopp, Roche / Sheng-Ching Wang, Merck & Co

13.15 – 13.30 Session intro

13.30 – 14.00 Advancing High-Throughput Chromatography Development: Leveraging a QSAR Model for Experimental Design and Applying Learnings to High-Throughput Methods
Michael Rauscher, Merck

14.00 – 14.30  Smart Bioprocessing Grand Challenge
Lucie Studena, CPI

14.30 – 15.00 Coffee

15.00 – 15.30 Just because you can doesn’t mean you should: What makes a successful high-throughput method
Tobias Hahn, Cytiva

15.30 – 16.00 Utilising machine learning for preventive maintenance and accelerating data analysis capabilities with digital transformation  
Razwan Hanif, UCB

16.00 – 16.30 Establishment of a High-Throughput Technology Roadmap across a Global Organization to Improve Purification Process Development for Biologics
Ludivine Profit, Sanofi

19.00 Conference Gala Dinner

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